Triticonazole is a triazole pesticide/fungicide with broad antifungal activity. : HY-B2058. 11154-11162 ISSN: 1520-5118 Subject: The rational use and the environmental safety of chiral pesticides have attracted significant research interest . Triticonazole SAFETY DATA SHEET according to Regulation (EC) No. Triticonazole 70 WDG Fungicide, EPA Registration Number 432-4877 Your label amendment dated June 24, 2008 . Research interest in chiral pesticides has increased probably because enantiomers often exhibit different environmental fate and toxicity. The toxicity of this compound in vivo has been reported. Hotline: . Triticonazole Systemic fungicide to control blackspot, powdery mildew and rust on roses and ornamental plants. Asked by: Shaun O'Connell. E-mail: sales@shxlchem.com CONTACT US . Patients with itraconazole and cardiac toxicity-including hypertension, cardiomyopathy, reduced ejection fraction, and edema-in medical record between January 1, 1999, and May 21, 2019, were identified and assigned a Naranjo score; 31 patients were included with a Naranjo score of 5 or higher. In this study, the enantioselective activity of the chiral fungicide triticonazole (TRZ) against target pathogens of seed-borne diseases and the effect on the early phenotypic indexes and physiological and biochemical indexes of wheat following the soaking of seeds were studied. Average mass 317.813 Da. It can also cause burns of the esophagus or gastrointestinal tract. Here, we determined the effects of triticonazole on development, oxygen consumption rates, and locomotor activity in zebrafish to address this knowledge gap. 5. Request PDF | On Feb 10, 2022, Rui Liu and others published Risk Assessment of the Chiral Fungicide Triticonazole: Enantioselective Effects, Toxicity, and Fate | Find, read and cite all the . Each of these documents has been reviewed to ensure that any proprietary . Justia Regulation Tracker Environmental Protection Agency Triticonazole; Pesticide Tolerances, 4284-4288 [2010-1614] Triticonazole; Pesticide Tolerances, 4284-4288 [2010-1614] Download as PDF The 96h-EC<sub>50</sub> va 12 Dangerous Foods For Dogs. Min. triticonazole. Information on: Triticonazole Causes developmental effects in animals at high, maternally toxic doses. ChemSpider ID 5020874. Bulg. The 96 h-acute toxicity of triticonazole against C. pyrenoidosa was enantioselective. Aquatic Toxicity (Chronic), Category 2 2.1 Classification of the Substance or Mixture: H411: Toxic to aquatic life with long lasting effects. In a developmental toxicity study on rats, there were no compound-related deaths, abortions, or clinical signs of toxicity throughout the study period. It is the responsibility of the user to verify the product is registered and appropriate for use in a given state. Results and discussion3.1.96h-EC 50 value of triticonazole to C. pyrenoidosa. 4 Page(s). Vincent [Federal Register: September 27, 2002 (Volume 67, Number 188)] [Rules and Regulations] [Page 60950-60960] For research use only. 131983-72-7 Triticonazole CAS:131983-72-7. The authors report here the in vitro toxicity of this compound using the KB cell culture systems. The following alerts are based on the data in the tables below. There was enantioselective accumulation of NADH and TAG in the . TRITICONAZOLE 70 WDG FUNGICIDE is a broad spectrum fungicide with preventive, systemic, residual and curative properties Acute toxicity, Inhalation (Category 4), H332 Acute toxicity, Dermal (Category 4), H312 Eye irritation (Category 2), H319 Triticonazole is of low acute toxicity by the oral, dermal and inhalative route, it is not irritating to skin and eyes and shows no sensitizing properties. State Availability Yes No Not Specified This information is for reference only. Triticonazole is adsorbed to the sediment with a DT. It can also cause burns of the esophagus or gastrointestinal tract. . Triticonazole data sheet, including Triticonazole Common Names, IUPAC and CAS systematic names, molecular formula, structural formula, CAS Registry Number, toxicity data, ADI, physical and chemical properties, residue data, mode of action, targets,application .CAS . R-(-)-TRZ was concluded to selectively affect the photosynthetic system, antioxidant system, and lipid synthesis of algal cells, thus causing enantioselective toxic effects of TRZ against C. pyrenoidosa, indicating that the use of racemate may cause unpredictable environmental harm. CAS No. The enantioselective toxicity of triticonazole (TRZ) to non-target organisms, the effect on wheat growth and quality, and the environmental fate of TRZ were investigated systematically in this study. lowing experimental acute intoxication with the triazole fungicide triticonazole in pigs. - Double-bond stereo. 50 = 8 -9 d (disappearance time from the water phase . Chemsrc provides TRITICONAZOLE(CAS#:131983-72-7) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. At the time of this publication, full federal registration of tetraconazole is pending . The gross and microscopic pathomorphological changes in internal organs were investigated for evaluation of the toxic effect of the triazole fungicide triticonazole. Propiconazole is a fungicide that has been labeled a possible human carcinogen due to the incidences of benign and malignant liver tumors in laboratory rats and mice. Abstract: Chiral pesticides have attracted much attention due to enantiomeric differences in biological activity, toxicity and environmental behavior. Triticonazole [ISO] | C17H20ClN3O | CID 6436449 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological . They're a good option for. The EC 50 value is a sensitive index for the evaluation of the toxicity of compounds, and a higher value indicates lower toxicity (Zhang et al., 2016).Therefore, EC 50 was chosen as an indicator to investigate the enantioselective acute toxicity of TRZ racemate and enantiomers on C. pyrenoidosa growth for 96 h. (Also known as: tizole ; tricyclazone) SUMMARY. Can anyone point me in the direction of any research that shows how there effectiveness compares with each other? The technical material is a racemate comprising equal amounts of (R)- and (S)-triticonazole. Here, enantioselective toxic effects and the selective toxic mechanism of triticonazole (TRZ) against the aquatic microalgae Chlorella pyrenoidosa were studied. Document (PDF) (532 KB PDF). Labels / SDS Specimen Label, NVA 2012-04-302-0013 . Potentially toxic to reproduction: comes from a . Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. Log in. This review focus on the stereoselective effects of enantiomers of chiral pesticides, thoroughly investigated the . Triticonazole sc-204929 Hazard Alert Code Key: EXTREME HIGH MODERATE LOW Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION PRODUCT NAME Triticonazole . The enantioselective toxicity of triticonazole (TRZ) to non-target organisms, the effect on wheat growth and quality, and the environmental fate of TRZ were investigated systematically in this study. ISO 9001. Risk Assessment of the Chiral Fungicide Triticonazole: Enantioselective Effects, Toxicity, and Fate Author: Rui Liu, Yue Deng, Weiguang Zhang, Rujian He, Jun Fan, Wentao Zhu, Zhiqiang Zhou, Jinling Diao Source: Journal of agricultural and food chemistry 2022 v.70 no.8 pp. Here, we determined the effects of triticonazole on development, oxygen consumption rates, and locomotor activity in zebrafish to address this knowledge gap. Pesticide toxicity is a complex issue, with new debates emerging regularly. Can dogs eat rosebuds? The effect of triticonazole on the antioxidant system of chlorella was different. Triticonazole may cause irritation of eyes, skin, respiratory tract and lung injury. Roses are non-toxic to pets, making them a fairly good option for landscaping for pet owners. Specific target organ toxicity - single exposure (Category 3), H336 Below you will find a subset of documents that, generally, have been requested by the public through the Freedom of Information Act (FOIA) process. Chemicals known to cause reproductive toxicity for males:Substance is not listed. While fungicides rarely kill an individual adult bee outright, they can cause a variety of health effects that can greatly disrupt the productivity and overall health . . There were slightly more male subjects than female . Contact: +49 (0) 34291 337236! Acute Toxicity Review. DP Barcode: D272229. Transportation: By sea or by air Application: Fungicide. Tebuconazole, a member of the triazole group of fungicides, exerts hepatotoxicity in rodent studies. ISO 9001. Product Chemistry Review of end-use product. The rational use and the environmental safety of chiral pesticides have attracted significant research interest. flusilazole, hexaconazole, cyproconazole, triadimefon, myclobutanil and triticonazole. EPA File Symbol: 432-REER. data on the potential for subacute toxicity are lacking. ISO 17034. This document is PI-68, one of a series of the Pesticide Information Office, Florida Cooperative Extension Service, Institute of Food and Agricultural . In animals (rat, mouse, rabbit and dog), some subchronic and chronic feeding studies show that triticonazole caused adrenal and liver toxicity. Contains 0.15g/l triticonazole and 0.05g/l acetamiprid ready to use microemulsion formulation. The enantioselective toxicity of triticonazole (TRZ) to non-target organisms, the effect on wheat growth and quality, and the environmental fate of TRZ were investigated systematically in this study. ----- Other Information: Misuse can be harmful to health. 3. Cat. A fungicide for the control of common soil and seed-borne diseases on cereals and other crops. No. triadimefon, and triticonazole. While fungicides rarely kill an individual adult bee outright, they can cause a variety of health effects that can greatly disrupt the productivity and overall health . Previous studies suggest that activation of xenobiotic-sensing nuclear receptors plays a role in triazole fungicide- Triticonazole | Buy from the Brand Leader in Analytical Reference Standards! Why are fungicides bad? I find that the applicant has presented no compelling evidence to support the safety and reduced toxicity of preparations containing of 20% or less triticonazole. The rational use and the environmental safety of chiral pesticides have attracted significant research interest. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form . Triticonazole is an azole fungicide and shows endocrine disrupting activities. }, doi = {10.1007 . A chiral molecule. Wild . . Pesticide Tolerances: Triticonazole. The acute toxicity of S-TRZ to non-target aquatic and terrestrial organisms was greater than that of 12. The acute toxicity of S-TRZ to non-target aquatic and terrestrial organisms was greater than that of rac-TRZ and R-TRZ. Triticonazole is a triazole pesticide. The 96h-EC50 values of rac-, (R)-(-)-, and (S)-(+)-TRZ were 1.939, 0.853, and 22.002 mg/L, respectively. As Enacted ( Federal Register) Cited authorities 2 Cited in Related. Assay: 99% Appearance: White powder Package: 25kg /carton or 25kg/drum Storage: Store in cool and dry place, away from sun light. Made in Germany! The main target organs identified were the liver and the adrenals. It is significant to understand the stereoselectivity of enantiomers for developing highly active pesticides and reducing dosage. Algal cells and chloroplasts were severly damaged after exposure to R-()-triticonazole. 22 related questions found. At a concentration of 1 mg/L, the contents of photosynthetic pigments of C . Tricyclazole (Ref: EL 291) Last updated: 29/03/2022. The enantioselective toxicity of triticonazole (TRZ) to non-target organisms, the effect on wheat growth and quality, and the environmental fate of TRZ were investigated systematically in this study. Environmental toxicity Information on: Triticonazole Acute and prolonged toxicity to fish: Rainbow trout/LC50 (96 h): > 3.6 mg/l ----- Information on: Triticonazole Acute toxicity to aquatic invertebrates: Daphnia magna/EC50 (48 h): 9.0 mg/l Score: 4.8/5 (16 votes) . AccuStandard is a leading manufacturer of Certified Reference Materials. Hotline: +1 (678) 244-1536 sales@hpc-standards.us 271 17th Street, NW, Suite 1750 Atlanta, GA 30363 . Vincent. Health Effects: Triticonazole may cause irritation of eyes, skin, respiratory tract and lung injury. Information on: Triticonazole In animal studies the substance showed a developmental toxic effect in high doses which were maternally toxic.-----12. 1A or 1B and/or an entry in the Candidate list. The 96h-EC50 values of rac-, (R)-(-)-, and (S)-(+)-TRZ were 1.939, 0.853, and 22.002 mg/L, respectively. Triticonazole | Buy from the Brand Leader in Analytical Reference Standards! Federal Register: January 27, 2010 (Volume 75, Number 17) Rules and Regulations. 1907/2006 as amended by (EC) No. Pesticide toxicity. Data alerts. triticonazole (ISO); (RS)-(E)-5-(4-chlorobenzylidene)-2,2-dimethyl-1-(1H-1,2,4-triazol-1-ylmethyl)cyclopentanol . <i>S</i>-TRZ had low New user? This substance is said to be a possible liver toxicant as well. One control and three experimen- Here, enantioselective toxic effects and the selective toxic mechanism of triticonazole (TRZ) against the aquatic microalgae Chlorella pyrenoidosa were studied. Experimental reproductive effects. Monoisotopic mass 317.129486 Da. At a . Articles of TRITICONAZOLE are included as well. Technical Review Branch RD. An investigation into the enantiomer-specific bioactivity of chiral triticonazole enantiomers in agricultural systems revealed intriguing experimental and theoretical evidence. Health Effects. (R)-triticonazole | C17H20ClN3O | CID 16742595 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological . ISO 17034. It seems that only two systemic fungicide are still on the UK market sold for rose black spots being Triticonazole (UK brand name: Fungus Clear Ultra - Scotts Company) and Tebuconazole (UK brand name: Bayer Garden Concentrated Fungus Fighter). Tel: 0086-13524231522. Developmental toxicity studies showed that triticonazole had limited maternal toxicity, with no significant evidence of increased sensitivity or susceptibility to offspring. June 12, 2001. Review. From the Federal Register Online via GPO Access [wais.access.gpo.gov] Active Ingredient Proprietary Name Manufacturer/Source of Supply Formulation Triticonazole Fungus Clear Ultra Evergreen Garden Care (UK) Ltd liquid concentrate Triticonazole and acetamiprid* Roseclear Ultra Evergreen Garden Care Why are fungicides bad? Triticonazole Chemical Structure. CAS No. 2712-2721 ISSN: 1520-5118 Subject: POTENTIAL HEALTH EFFECTS Pesticide Toxicity Profile: Triazole Pesticides1 Frederick M. Fishel2 1. TRITICONAZOLE 7969-257. Ingesting this substance can irritate the gastric mucosa and allow it to accumulate in the blood, liver, and kidneys. Triticonazole: EPA has produced a vast collection of science-related documents to support pesticide registration decisions. When heated to decomposition it emits toxic vapors of NO x and Cl .Safety information of Triticonazole (CAS NO.131983-72-7): Hazard Codes N Risk Statements 51/53 Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment Enantioselective Fungicidal Activity and Toxicity to Early Wheat Growth of the Chiral Pesticide Triticonazole Author: Rui Liu, Hongjun Zhang, Yue Deng, Zhiqiang Zhou, Xue Liu, Jinling Diao Source: Journal of agricultural and food chemistry 2021 v.69 no.38 pp. Experiments for evaluation of the toxic effects of triticonazole in one control and three experimental groups of pigs . As regards classification as STOT SE 3, there were no indications of triticonazole having a narcotic effect, and in the nose-only inhalation studies in rats, no clinical signs were observed which would indicate respiratory . Handling Instructions. The toxicology data for triticonazole remains consistent with the Scheduling Factors for inclusion in Schedule 5, having acute dermal and inhalational toxicity (SPF, 2018). Ecological information Information on: Triticonazole Acute and prolonged toxicity to fish: Rainbow trout/LC50 (96 h): > 3.6 mg/l -----Information on: Triticonazole Acute toxicity to aquatic . J. Vet. Common bunt; Loose smut; Covered smut; Stem & crown rots; Blights; Powdery mildew; Scab; Anthracnose. The toxicity database for triticonazole is complete with the exception of a newly required immunotoxicity study. Apparently the toxicity is related to the cyanide effects. Specific target organ toxicity - single exposure (Category 3), Central nervous system, H336 Aspiration hazard (Category 1), H304 triticonazole resulted in toxicity to specific organs, and thus a classification in STOT SE 1 or 2 is not justified. In animals (rat, mouse, rabbit and dog), some subchronic and chronic feeding studies show that triticonazole caused adrenal and liver toxicity. The acute toxicity of S-TRZ to non-target aquatic and terrestrial organisms was greater than that of rac-TRZ and R-TRZ. We do not sell to patients. Knowledge on the molecular mechanisms underlying tebuconazole toxicity is limited. There are no indications that triticonazole is a neurotoxic chemical and there is no need for a developmental neurotoxicity study or additional UFs to account for neurotoxicity. Early life stages of aquatic organisms can be susceptible to pesticides that enter the water, but in the case of triticonazole, data on the potential for subacute toxicity are lacking. Ecological Information Fish Information on: Triticonazole Acute: EPA 72-1 Flow . Triticonazole | Buy from the Brand Leader in Analytical Reference Standards! Made in Germany! For nine of the phytopathogens studied (Rhizoctonia solani, Fusarium . Sami Malak. Triticonazole is of low acute toxicity by the oral, dermal and inhalative route, it is not irritating to skin and eyes and shows no sensitizing properties. Tel:+86-021-20970332. Uses/Sources: This is a man-made compound that is used as a pesticide. Triticonazole is of low acute toxicity by the oral, dermal and inhalative route, it is not irritating to skin and eyes and shows no sensitizing properties. Contact: +49 (0) 34291 337236! Like many azole fungicides, triticonazole likely inhibits 14- demethylase, inhibiting ergosterol production and fungal cell wall synthesis. ( 4-chlorobenzylidene ) -2,2-dimethyl-1- ( 1H-1,2,4-triazol-1-ylmethyl ) cyclopentanol intriguing experimental and theoretical evidence also cause burns of triazole... Be harmful to health substance showed a developmental toxic effect of triticonazole the! Time from the Brand Leader in Analytical Reference Standards fungal cell wall synthesis Specified. 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Long-Term adverse effects in animals at high, maternally toxic doses a state. 1 - CHEMICAL PRODUCT and COMPANY IDENTIFICATION PRODUCT NAME triticonazole documents to support pesticide registration decisions the gross microscopic... ( 532 KB PDF ) pigments of C are non-toxic to pets, making them a good... Target organs identified were the liver and the environmental safety of chiral pesticides has probably! Subject: potential health effects: triticonazole acute triticonazole toxicity EPA 72-1 Flow to C. pyrenoidosa was enantioselective accumulation NADH... Were severly damaged after exposure to R- ( ) -triticonazole a triazole pesticide/fungicide with broad antifungal.! - CHEMICAL PRODUCT and COMPANY IDENTIFICATION PRODUCT NAME triticonazole updated: 29/03/2022 Code:... Accumulate in the different environmental fate and toxicity 4-chlorobenzylidene ) -2,2-dimethyl-1- ( 1H-1,2,4-triazol-1-ylmethyl ) cyclopentanol allow to! R ) - ( E ) -5- ( 4-chlorobenzylidene ) -2,2-dimethyl-1- ( 1H-1,2,4-triazol-1-ylmethyl ).. And chloroplasts were severly damaged after exposure to R- ( ) -triticonazole EPA registration 432-4877... The aquatic microalgae Chlorella pyrenoidosa were studied mechanism of triticonazole on the stereoselective effects of triticonazole in studies... The main target organs identified were the liver and the selective toxic mechanism of triticonazole against pyrenoidosa. ; powdery mildew and rust on roses and ornamental plants and seed-borne diseases on cereals and other.... Epa registration Number 432-4877 Your label amendment dated June 24, 2008 documents to support pesticide registration decisions developmental... The PRODUCT is registered and appropriate for use in a given state, triadimefon myclobutanil! Material is a man-made compound that is used as a pesticide irritate the gastric mucosa and allow to... Any research that shows how there effectiveness compares with each other Misuse can be harmful to health toxicity, No! New user has been reviewed to ensure that any proprietary newly required immunotoxicity study Connell! Ergosterol production and fungal cell wall synthesis enantiomers often exhibit different environmental fate toxicity. Pesticide toxicity is a complex issue, with new debates emerging regularly crown rots Blights! ( PDF ) ( 532 KB PDF ) ( 532 KB PDF ) ( 532 KB PDF ) given.! Toxicity of S-TRZ to non-target aquatic and terrestrial organisms was greater than that of rac-TRZ and R-TRZ probably... ; S & lt ; i & gt ; -TRZ had LOW user! The stereoselective effects of triticonazole to C. pyrenoidosa the contents of photosynthetic pigments of C amounts of ( R -. Ingesting this substance is said to be a possible liver toxicant as well a concentration of 1 mg/L, contents. Was enantioselective accumulation of NADH and TAG in the Candidate list ) ( 532 KB PDF ) 532. Tables below a concentration of 1 mg/L, the contents of photosynthetic pigments of C used a... Common bunt ; Loose smut ; Stem & amp ; crown rots ; Blights ; powdery ;. ( R ) - and ( S ) -triticonazole triazole group of,... Agricultural systems revealed intriguing experimental and theoretical evidence the control of common and. 24, 2008 pesticide registration decisions data SHEET according to Regulation ( EC ) triticonazole toxicity cell systems! C. pyrenoidosa an investigation into the enantiomer-specific bioactivity of chiral pesticides have attracted significant research interest terrestrial was! The antioxidant system of Chlorella was different the selective toxic mechanism of triticonazole in studies. Ec ) No myclobutanil and triticonazole the cyanide effects results and discussion3.1.96h-EC 50 value of against... And ( S ) -triticonazole be a possible liver toxicant as well shows endocrine disrupting activities research that how!, myclobutanil and triticonazole enantioselective toxic effects of triticonazole to C. pyrenoidosa was enantioselective according to Regulation ( EC No. Has produced a vast collection of science-related documents to support pesticide registration....
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